First you have to
- test that layout in as many email clients as possible
- on as many platforms as possible.
Don't forget about Web-based email services like Hotmail or Yahoo! Mail either. Now you can celebrate!
If you don't have access to Macs or Unix machines and don't have an account with every major Web-based system, try asking friends and relatives if they would be willing to test an issue 0.1 for you (for an invitation to dinner maybe).
Make this layout and rendering test a routine. Whenever you make a change to your newsletter template, test it. The smallest changes can have the most surprising effects.

